About Dihydropyrimidinase-related protein 4
Dihydropyrimidinase-related protein 4 (DPYSL4) is a protein
from Homo sapiens identified by UniProt accession
O14531, 572 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Dihydropyrimidinase-related protein 4 |
|---|
| UniProt accession | O14531 |
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| Gene | DPYSL4 |
|---|
| Organism | Homo sapiens |
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| Length | 572 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- body mass index · score 0.41
- body weight · score 0.39
- lean body mass · score 0.32
- body fat percentage · score 0.26
- brain measurement · score 0.24
- risk-taking behaviour · score 0.24
- fat body mass · score 0.24
- cortical thickness · score 0.22
- mathematical ability · score 0.21
- waist circumference · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14531-F1 | alphafold | PREDICTED | 90.09 | — |
Amino-acid sequence (572 residues)
MSFQGKKSIP RITSDRLLIR GGRIVNDDQS FYADVHVEDG LIKQIGENLI VPGGIKTIDA HGLMVLPGGV DVHTRLQMPV LGMTPADDFC QGTKAALAGG TTMILDHVFP DTGVSLLAAY EQWRERADSA ACCDYSLHVD ITRWHESIKE ELEALVKEKG VNSFLVFMAY KDRCQCSDSQ MYEIFSIIRD LGALAQVHAE NGDIVEEEQK RLLELGITGP EGHVLSHPEE VEAEAVYRAV TIAKQANCPL YVTKVMSKGA ADAIAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA FVTSPPVNPD PTTADHLTCL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFAL IPEGTNGIEE RMSMVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR VAVGSDADLV IWNPKATKII SAKTHNLNVE YNIFEGVECR GAPAVVISQG RVALEDGKMF VTPGAGRFVP RKTFPDFVYK RIKARNRLAE IHGVPRGLYD GPVHEVMVPA KPGSGAPARA SCPGKISVPP VRNLHQSGFS LSGSQADDHI ARRTAQKIMA PPGGRSNITS LS
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