About TRAF-type zinc finger domain-containing protein 1
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) is a protein
from Homo sapiens identified by UniProt accession
O14545, 582 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | TRAF-type zinc finger domain-containing protein 1 |
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| UniProt accession | O14545 |
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| Gene | TRAFD1 |
|---|
| Organism | Homo sapiens |
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| Length | 582 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.31
- cystatin C measurement · score 0.25
- eosinophil percentage of leukocytes · score 0.23
- reticulocyte count · score 0.16
- platelet count · score 0.14
- high density lipoprotein cholesterol measurement · score 0.13
- genetic disorder · score 0.12
- hemoglobin measurement · score 0.10
- mean corpuscular volume · score 0.08
- alcohol drinking · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14545-F1 | alphafold | PREDICTED | 57.87 | — |
Amino-acid sequence (582 residues)
MAEFLDDQET RLCDNCKKEI PVFNFTIHEI HCQRNIGMCP TCKEPFPKSD METHMAAEHC QVTCKCNKKL EKRLLKKHEE TECPLRLAVC QHCDLELSIL KLKEHEDYCG ARTELCGNCG RNVLVKDLKT HPEVCGREGE EKRNEVAIPP NAYDESWGQD GIWIASQLLR QIEALDPPMR LPRRPLRAFE SDVFHNRTTN QRNITAQVSI QNNLFEEQER QERNRGQQPP KEGGEESANL DFMLALSLQN EGQASSVAEQ DFWRAVCEAD QSHGGPRSLS DIKGAADEIM LPCEFCEELY PEELLIDHQT SCNPSRALPS LNTGSSSPRG VEEPDVIFQN FLQQAASNQL DSLMGLSNSH PVEESIIIPC EFCGVQLEEE VLFHHQDQCD QRPATATNHV TEGIPRLDSQ PQETSPELPR RRVRHQGDLS SGYLDDTKQE TANGPTSCLP PSRPINNMTA TYNQLSRSTS GPRPGCQPSS PCVPKLSNSD SQDIQGRNRD SQNGAIAPGH VSVIRPPQNL YPENIVPSFS PGPSGRYGAS GRSEGGRNSR VTPAAANYRS RTAKAKPSKQ QGAGDAEEEE EE
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