About Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS) is a protein
from Homo sapiens identified by UniProt accession
O14556, 408 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
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| UniProt accession | O14556 |
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| Gene | GAPDHS |
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| Organism | Homo sapiens |
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| Length | 408 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (115)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- platelet count · score 0.24
- squamous cell lung carcinoma · score 0.19
- serum alanine aminotransferase measurement · score 0.18
- Intrahepatic cholestasis of pregnancy · score 0.17
- cholestasis, intrahepatic, of pregnancy 3 · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14556-F1 | alphafold | PREDICTED | 89.19 | — |
Amino-acid sequence (408 residues)
MSKRDIVLTN VTVVQLLRQP CPVTRAPPPP EPKAEVEPQP QPEPTPVREE IKPPPPPLPP HPATPPPKMV SVARELTVGI NGFGRIGRLV LRACMEKGVK VVAVNDPFID PEYMVYMFKY DSTHGRYKGS VEFRNGQLVV DNHEISVYQC KEPKQIPWRA VGSPYVVEST GVYLSIQAAS DHISAGAQRV VISAPSPDAP MFVMGVNEND YNPGSMNIVS NASCTTNCLA PLAKVIHERF GIVEGLMTTV HSYTATQKTV DGPSRKAWRD GRGAHQNIIP ASTGAAKAVT KVIPELKGKL TGMAFRVPTP DVSVVDLTCR LAQPAPYSAI KEAVKAAAKG PMAGILAYTE DEVVSTDFLG DTHSSIFDAK AGIALNDNFV KLISWYDNEY GYSHRVVDLL RYMFSRDK
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