About Rho GTPase-activating protein 33
Rho GTPase-activating protein 33 (ARHGAP33) is a protein
from Homo sapiens identified by UniProt accession
O14559, 1287 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Rho GTPase-activating protein 33 |
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| UniProt accession | O14559 |
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| Gene | ARHGAP33 |
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| Organism | Homo sapiens |
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| Length | 1287 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- body height · score 0.22
- Red cell distribution width · score 0.06
- self reported educational attainment · score 0.05
- blood protein measurement · score 0.04
- schizophrenia · score 0.04
- age at first sexual intercourse measurement · score 0.03
- cortical surface area measurement · score 0.03
- white matter microstructure measurement · score 0.03
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14559-F1 | alphafold | PREDICTED | 53.32 | — |
Amino-acid sequence (1287 residues)
MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA AGLGALSGSP SHRTSAWLDD GDELDFSPPR CLEGLRGLDF DPLTFRCSSP TPGDPAPPAS PAPPAPASAF PPRVTPQAIS PRGPTSPASP AALDISEPLA VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL LRGAEAPLTD ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG PPPNSLAHPG AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS AQLRAGGGGR DAPEAAAQSP CSVPSQVPTP GFFSPAPREC LPPFLGVPKP GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD RGENLYYEIG ASEGSPYSGP TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP APSCFPPDHL GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR GSLYRNGGQR GEGAGPPPPY PTPSWSLHSE GQTRSYC
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