About Transmembrane reductase CYB561D2
Transmembrane reductase CYB561D2 (CYB561D2) is a protein
from Homo sapiens identified by UniProt accession
O14569, 222 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Transmembrane reductase CYB561D2 |
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| UniProt accession | O14569 |
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| Gene | CYB561D2 |
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| Organism | Homo sapiens |
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| Length | 222 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- lysosomal storage disease · score 0.37
- reticulocyte measurement · score 0.33
- reticulocyte count · score 0.27
- lymphocyte count · score 0.22
- schizophrenia · score 0.15
- Immature Reticulocyte Fraction Measurement · score 0.07
- wellbeing measurement · score 0.07
- neurotic disorder · score 0.07
- lymphocyte percentage of leukocytes · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14569-F1 | alphafold | PREDICTED | 93.75 | — |
Amino-acid sequence (222 residues)
MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV LMSLAFSFLM TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG LGLVILHKEQ LGKAHLVTRH GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW PLAKLKLYHA TSGLVGYLLG SASLLLGMCS LWFTASVTGA AWYLAVLCPV LTSLVIMNQV SNAYLYRKRI QP
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