About Cytoplasmic dynein 1 intermediate chain 1
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) is a protein
from Homo sapiens identified by UniProt accession
O14576, 645 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Cytoplasmic dynein 1 intermediate chain 1 |
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| UniProt accession | O14576 |
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| Gene | DYNC1I1 |
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| Organism | Homo sapiens |
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| Length | 645 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (73)
Diseases linked to this target (Open Targets).
- viral disease · score 0.46
- heel bone mineral density · score 0.45
- asthma · score 0.43
- vital capacity · score 0.41
- blood protein measurement · score 0.30
- bone quantitative ultrasound measurement · score 0.28
- spinal stenosis · score 0.27
- response to vaccine · score 0.27
- cytokine measurement · score 0.27
- age-related hearing impairment · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14576-F1 | alphafold | PREDICTED | 70.96 | — |
Amino-acid sequence (645 residues)
MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA
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