About Coatomer subunit epsilon
Coatomer subunit epsilon (COPE) is a protein
from Homo sapiens identified by UniProt accession
O14579, 308 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Coatomer subunit epsilon |
|---|
| UniProt accession | O14579 |
|---|
| Gene | COPE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 308 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- Alzheimer disease · score 0.24
- Parkinson disease · score 0.24
- multiple sclerosis · score 0.24
- lysosomal storage disease · score 0.24
- breast adenocarcinoma · score 0.10
- obstructive sleep apnea · score 0.03
- myxosarcoma · score 0.01
- dengue disease · score 0.01
- Plasmodium falciparum malaria · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14579-F1 | alphafold | PREDICTED | 89.37 | — |
Amino-acid sequence (308 residues)
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL VLQYAPSA
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