About Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (CTDSP2) is a protein
from Homo sapiens identified by UniProt accession
O14595, 271 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 |
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| UniProt accession | O14595 |
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| Gene | CTDSP2 |
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| Organism | Homo sapiens |
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| Length | 271 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- body height · score 0.29
- platelet component distribution width · score 0.26
- erythrocyte count · score 0.26
- hematocrit · score 0.26
- adolescent idiopathic scoliosis · score 0.26
- sitting height measurement · score 0.23
- hemoglobin measurement · score 0.23
- BMI-adjusted waist circumference · score 0.21
- trochanter size · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14595-F1 | alphafold | PREDICTED | 78.35 | — |
Amino-acid sequence (271 residues)
MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRNIFKA LFCCFRAQHV GQSSSSTELA AYKEEANTIA KSDLLQCLQY QFYQIPGTCL LPEVTEEDQG RICVVIDLDE TLVHSSFKPI NNADFIVPIE IEGTTHQVYV LKRPYVDEFL RRMGELFECV LFTASLAKYA DPVTDLLDRC GVFRARLFRE SCVFHQGCYV KDLSRLGRDL RKTLILDNSP ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA P
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