Eukaryotic translation initiation factor 1A…

About Eukaryotic translation initiation factor 1A, Y-chromosomal

Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY) is a protein from Homo sapiens identified by UniProt accession O14602, 144 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 1A, Y-chromosomal
UniProt accession	O14602
Gene	EIF1AY
Organism	Homo sapiens
Length	144 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

Ataxia-telangiectasia · score 0.06
breast carcinoma · score 0.05
cystic fibrosis · score 0.05
amyotrophic lateral sclerosis · score 0.05
multiple sclerosis · score 0.05
Adams-Oliver syndrome · score 0.04
Sepsis · score 0.01
visceral Leishmaniasis · score 0.01
spina bifida · score 0.01
rosacea · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14602-F1	alphafold	PREDICTED	77.40	—

Amino-acid sequence (144 residues)

MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY)