Guanine nucleotide-binding protein G(I)/G(S)/G(O)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 (GNGT2) is a protein from Homo sapiens identified by UniProt accession O14610, 69 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
UniProt accession	O14610
Gene	GNGT2
Organism	Homo sapiens
Length	69 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

refractive error · score 0.35
Hypermetropia · score 0.33
Myopia · score 0.31
Abnormality of refraction · score 0.29
glioblastoma multiforme · score 0.28
refractive error measurement · score 0.27
lung adenocarcinoma · score 0.23
male reproductive organ cancer · score 0.17
asthma · score 0.16
monocyte count · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14610-F1	alphafold	PREDICTED	89.74	—

Amino-acid sequence (69 residues)

MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL KGIPEDKNPF KEKGGCLIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 (GNGT2)