Copper chaperone for superoxide dismutase (CCS)

About Copper chaperone for superoxide dismutase

Copper chaperone for superoxide dismutase (CCS) is a protein from Homo sapiens identified by UniProt accession O14618, 274 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	Copper chaperone for superoxide dismutase
UniProt accession	O14618
Gene	CCS
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
breast adenocarcinoma · score 0.18
Neurodegeneration · score 0.11
axial length measurement · score 0.08
forced expiratory volume · score 0.07
primary ovarian insufficiency · score 0.04
insomnia measurement · score 0.04
familial hyperprolactinemia · score 0.04
46,XX testicular disorder of sex development · score 0.04
46,XX ovotesticular disorder of sex development · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14618-F1	alphafold	PREDICTED	87.36	—

Amino-acid sequence (274 residues)

MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards