About G-protein coupled receptor 171
G-protein coupled receptor 171 (GPR171) is a protein
from Homo sapiens identified by UniProt accession
O14626, 319 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | G-protein coupled receptor 171 |
|---|
| UniProt accession | O14626 |
|---|
| Gene | GPR171 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 319 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.14
- eosinophil percentage of leukocytes · score 0.12
- neoplasm · score 0.08
- chronotype measurement · score 0.08
- cancer · score 0.06
- insomnia measurement · score 0.04
- breast cancer · score 0.02
- Acute hepatic failure · score 0.02
- anxiety · score 0.02
- lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14626-F1 | alphafold | PREDICTED | 87.72 | — |
Amino-acid sequence (319 residues)
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF ASPKETKAQK EKLRCENNA
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