About Homeobox protein CDX-4
Homeobox protein CDX-4 (CDX4) is a protein
from Homo sapiens identified by UniProt accession
O14627, 284 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Homeobox protein CDX-4 |
|---|
| UniProt accession | O14627 |
|---|
| Gene | CDX4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 284 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- autosomal recessive spondylocostal dysostosis · score 0.05
- acute myeloid leukemia · score 0.03
- glioblastoma multiforme · score 0.02
- acute lymphoblastic leukemia · score 0.02
- acute erythroleukemia · score 0.01
- alveolar rhabdomyosarcoma · score 0.01
- neoplasm · score 0.01
- embryonal carcinoma · score 0.01
- Acute Leukemia · score 0.00
- esophageal squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14627-F1 | alphafold | PREDICTED | 61.78 | — |
Amino-acid sequence (284 residues)
MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE
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