Late cornified envelope protein 2B (LCE2B)

About Late cornified envelope protein 2B

Late cornified envelope protein 2B (LCE2B) is a protein from Homo sapiens identified by UniProt accession O14633, 110 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Late cornified envelope protein 2B
UniProt accession	O14633
Gene	LCE2B
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
breast adenocarcinoma · score 0.22
prostate adenocarcinoma · score 0.21
esophageal cancer · score 0.17
gastric adenocarcinoma · score 0.16
urinary bladder cancer · score 0.11
low grade glioma · score 0.11
squamous cell lung carcinoma · score 0.11
endometrial cancer · score 0.10
psoriasis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14633-F1	alphafold	PREDICTED	52.11	—

Amino-acid sequence (110 residues)

MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCLPQCPAPC SPAVSSCCGP ISGGCCGPSS GGCCNSGAGG CCLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards