About Segment polarity protein dishevelled homolog DVL-1
Segment polarity protein dishevelled homolog DVL-1 (DVL1) is a protein
from Homo sapiens identified by UniProt accession
O14640, 695 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Segment polarity protein dishevelled homolog DVL-1 |
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| UniProt accession | O14640 |
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| Gene | DVL1 |
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| Organism | Homo sapiens |
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| Length | 695 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (184)
Diseases linked to this target (Open Targets).
- autosomal dominant Robinow syndrome · score 0.65
- Robinow syndrome · score 0.56
- genetic disorder · score 0.42
- endometrial cancer · score 0.23
- lung adenocarcinoma · score 0.10
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.08
- cancer · score 0.08
- breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14640-F1 | alphafold | PREDICTED | 59.85 | — |
Amino-acid sequence (695 residues)
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG APQLEEAPLT VKSDMSAVVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSLLKHGFL RHTVNKITFS EQCYYVFGDL CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY QYPGPPPCFP PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA YTVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM
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