About Segment polarity protein dishevelled homolog DVL-2
Segment polarity protein dishevelled homolog DVL-2 (DVL2) is a protein
from Homo sapiens identified by UniProt accession
O14641, 736 residues long.
MolForge cross-references it against 0 known binders and
178 disease associations.
Target properties
| Protein name | Segment polarity protein dishevelled homolog DVL-2 |
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| UniProt accession | O14641 |
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| Gene | DVL2 |
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| Organism | Homo sapiens |
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| Length | 736 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (178)
Diseases linked to this target (Open Targets).
- Robinow syndrome · score 0.37
- diastolic blood pressure · score 0.29
- systolic blood pressure · score 0.28
- glioblastoma multiforme · score 0.24
- endometrial cancer · score 0.23
- serum urea measurement · score 0.22
- lung adenocarcinoma · score 0.21
- serum alanine aminotransferase measurement · score 0.18
- diet measurement · score 0.15
- creatinine measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14641-F1 | alphafold | PREDICTED | 58.67 | — |
Amino-acid sequence (736 residues)
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
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