About Axonemal dynein light intermediate polypeptide 1
Axonemal dynein light intermediate polypeptide 1 (DNALI1) is a protein
from Homo sapiens identified by UniProt accession
O14645, 258 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Axonemal dynein light intermediate polypeptide 1 |
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| UniProt accession | O14645 |
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| Gene | DNALI1 |
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| Organism | Homo sapiens |
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| Length | 258 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (135)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.29
- malignant epithelial tumor of ovary · score 0.24
- intraocular pressure measurement · score 0.23
- refractive error measurement · score 0.19
- forced expiratory volume · score 0.17
- ovarian carcinoma · score 0.15
- body mass index · score 0.12
- body height · score 0.10
- azoospermia · score 0.09
- unipolar depression · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14645-F1 | alphafold | PREDICTED | 84.40 | — |
Amino-acid sequence (258 residues)
MIPPADSLLK YDTPVLVSRN TEKRSPKARL LKVSPQQPGP SGSAPQPPKT KLPSTPCVPD PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV HLQEQLDLKL QQRQARETGI CPVRRELYSQ CFDELIREVT INCAERGLLL LRVRDEIRMT IAAYQTLYES SVAFGMRKAL QAEQGKSDME RKIAELETEK RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK RTNQQLKAQL EGIIAPKK
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