About Transmembrane gamma-carboxyglutamic acid protein 1
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) is a protein
from Homo sapiens identified by UniProt accession
O14668, 218 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Transmembrane gamma-carboxyglutamic acid protein 1 |
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| UniProt accession | O14668 |
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| Gene | PRRG1 |
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| Organism | Homo sapiens |
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| Length | 218 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (10)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.01
- pancreatic ductal adenocarcinoma · score 0.01
- astrocytoma · score 0.00
- triple-negative breast cancer · score 0.00
- pancreatic carcinoma · score 0.00
- myelodysplastic syndrome · score 0.00
- Down syndrome · score 0.00
- ulcerative colitis · score 0.00
- atherosclerosis · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14668-F1 | alphafold | PREDICTED | 67.89 | — |
Amino-acid sequence (218 residues)
MGRVFLTGEK ANSILKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK
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