About Transmembrane gamma-carboxyglutamic acid protein 2
Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2) is a protein
from Homo sapiens identified by UniProt accession
O14669, 202 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Transmembrane gamma-carboxyglutamic acid protein 2 |
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| UniProt accession | O14669 |
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| Gene | PRRG2 |
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| Organism | Homo sapiens |
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| Length | 202 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.21
- body height · score 0.17
- skin aging measurement · score 0.17
- schizophrenia · score 0.16
- fibrinogen measurement · score 0.15
- hematocrit · score 0.13
- erythrocyte count · score 0.13
- red blood cell density measurement · score 0.11
- apolipoprotein A 1 measurement · score 0.10
- cortical surface area measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14669-F1 | alphafold | PREDICTED | 72.04 | — |
Amino-acid sequence (202 residues)
MRGHPSLLLL YMALTTCLDT SPSEETDQEV FLGPPEAQSF LSSHTRIPRA NHWDLELLTP GNLERECLEE RCSWEEAREY FEDNTLTERF WESYIYNGKG GRGRVDVASL AVGLTGGILL IVLAGLGAFW YLRWRQHRGQ QPCPQEAGLI SPLSPLNPLG PPTPLPPPPP PPPGLPTYEQ ALAASGVHDA PPPPYTSLRR PH
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