About Disintegrin and metalloproteinase domain-containing protein 10
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is a protein
from Homo sapiens identified by UniProt accession
O14672, 748 residues long.
MolForge cross-references it against 0 known binders and
382 disease associations.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 10 |
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| UniProt accession | O14672 |
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| Gene | ADAM10 |
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| Organism | Homo sapiens |
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| Length | 748 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (382)
Diseases linked to this target (Open Targets).
- reticulate acropigmentation of Kitamura · score 0.66
- Alzheimer disease 18 · score 0.58
- body mass index · score 0.39
- Alzheimer disease · score 0.37
- family history of Alzheimer’s disease · score 0.35
- late-onset Alzheimers disease · score 0.33
- head and neck squamous cell carcinoma · score 0.30
- schizophrenia · score 0.29
- high density lipoprotein cholesterol measurement · score 0.27
- diastolic blood pressure · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14672-F1 | alphafold | PREDICTED | 80.05 | — |
Amino-acid sequence (748 residues)
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL KRRRPPQPIQ QPQRQRPRES YQMGHMRR
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