Prostaglandin E synthase (PTGES)

About Prostaglandin E synthase

Prostaglandin E synthase (PTGES) is a protein from Homo sapiens identified by UniProt accession O14684, 152 residues long. MolForge cross-references it against 0 known binders and 285 disease associations.

Target properties

Protein name	Prostaglandin E synthase
UniProt accession	O14684
Gene	PTGES
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (285)

Diseases linked to this target (Open Targets).

asthma · score 0.31
neoplasm · score 0.09
pancreatic neoplasm · score 0.08
colitis · score 0.07
laryngeal neoplasm · score 0.05
melanoma · score 0.05
lymphatic malformation 3 · score 0.04
Lipedema · score 0.04
serum alanine aminotransferase measurement · score 0.04
colorectal adenocarcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14684-F1	alphafold	PREDICTED	96.05	—

Amino-acid sequence (152 residues)

MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR HL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards