tRNA (cytosine(38)-C(5))-methyltransferase (TRDMT1)

About tRNA (cytosine(38)-C(5))-methyltransferase

tRNA (cytosine(38)-C(5))-methyltransferase (TRDMT1) is a protein from Homo sapiens identified by UniProt accession O14717, 391 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	tRNA (cytosine(38)-C(5))-methyltransferase
UniProt accession	O14717
Gene	TRDMT1
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

platelet count · score 0.44
Red cell distribution width · score 0.40
platelet component distribution width · score 0.38
neurodegenerative disease · score 0.37
mean corpuscular volume · score 0.36
platelet crit · score 0.36
HbA1c measurement · score 0.31
hemoglobin A1 measurement · score 0.31
total cholesterol measurement · score 0.29
homocysteine measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14717-F1	alphafold	PREDICTED	87.06	—

Amino-acid sequence (391 residues)

MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT QLLAKTIEGI TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL HILDILPRLQ KLPKYILLEN VKGFEVSSTR DLLIQTIENC GFQYQEFLLS PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG QVLMEFPKIE SVHPQKYAMD VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR KNQQDSDLSV KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN LLGFPPEFGF PEKITVKQRY RLLGNSLNVH VVAKLIKILY E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards