About Serine/threonine-protein kinase RIO3
Serine/threonine-protein kinase RIO3 (RIOK3) is a protein
from Homo sapiens identified by UniProt accession
O14730, 519 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase RIO3 |
|---|
| UniProt accession | O14730 |
|---|
| Gene | RIOK3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 519 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (56)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.67
- reticulocyte measurement · score 0.67
- Immature Reticulocyte Fraction Measurement · score 0.56
- platelet count · score 0.28
- body weights and measures · score 0.26
- neuroinflammatory disorder · score 0.19
- waist-hip ratio · score 0.19
- body height · score 0.18
- platelet crit · score 0.15
- genetic disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14730-F1 | alphafold | PREDICTED | 74.29 | — |
Amino-acid sequence (519 residues)
MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE EEAAVFPEVA VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPVPT PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPEFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV LLKKHILVMS FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVKEALS ERELFNAVSG LNITADNEAD FLAEIEALEK MNEDHVQKNG RKAASFLKDD GDPPLLYDE
Explore Serine/threonine-protein kinase RIO3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets