About Inositol monophosphatase 2
Inositol monophosphatase 2 (IMPA2) is a protein
from Homo sapiens identified by UniProt accession
O14732, 288 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Inositol monophosphatase 2 |
|---|
| UniProt accession | O14732 |
|---|
| Gene | IMPA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- hemoglobin measurement · score 0.36
- hematocrit · score 0.35
- red blood cell density measurement · score 0.28
- body height · score 0.27
- erythrocyte count · score 0.27
- reticulocyte count · score 0.26
- endometrial cancer · score 0.18
- nonpapillary renal cell carcinoma · score 0.09
- appendicular lean mass · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14732-F1 | alphafold | PREDICTED | 94.71 | — |
Amino-acid sequence (288 residues)
MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
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