About Dual specificity mitogen-activated protein kinase kinase 7
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) is a protein
from Homo sapiens identified by UniProt accession
O14733, 419 residues long.
MolForge cross-references it against 0 known binders and
806 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 7 |
|---|
| UniProt accession | O14733 |
|---|
| Gene | MAP2K7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 419 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (806)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- neuroinflammatory disorder · score 0.43
- anthrax infection · score 0.37
- Parkinson disease · score 0.36
- multiple sclerosis · score 0.36
- lysosomal storage disease · score 0.36
- Alzheimer disease · score 0.36
- type 2 diabetes mellitus · score 0.26
- sex hormone-binding globulin measurement · score 0.26
- diabetes mellitus · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14733-F1 | alphafold | PREDICTED | 77.27 | — |
Amino-acid sequence (419 residues)
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR
Explore Dual specificity mitogen-activated protein kinase kinase 7 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets