About Acyl-coenzyme A thioesterase 8
Acyl-coenzyme A thioesterase 8 (ACOT8) is a protein
from Homo sapiens identified by UniProt accession
O14734, 319 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Acyl-coenzyme A thioesterase 8 |
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| UniProt accession | O14734 |
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| Gene | ACOT8 |
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| Organism | Homo sapiens |
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| Length | 319 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- nonpapillary renal cell carcinoma · score 0.08
- body height · score 0.05
- vital capacity · score 0.04
- hepatocellular carcinoma · score 0.03
- mean platelet volume · score 0.03
- neoplasm · score 0.02
- cancer · score 0.01
- HIV infection · score 0.01
- Alzheimer disease · score 0.01
- lymph node metastatic carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14734-F1 | alphafold | PREDICTED | 88.06 | — |
Amino-acid sequence (319 residues)
MSSPQAPEDG QGCGDRGDPP GDLRSVLVTT VLNLEPLDED LFRGRHYWVP AKRLFGGQIV GQALVAAAKS VSEDVHVHSL HCYFVRAGDP KLPVLYQVER TRTGSSFSVR SVKAVQHGKP IFICQASFQQ AQPSPMQHQF SMPTVPPPEE LLDCETLIDQ YLRDPNLQKR YPLALNRIAA QEVPIEIKPV NPSPLSQLQR MEPKQMFWVR ARGYIGEGDM KMHCCVAAYI SDYAFLGTAL LPHQWQHKVH FMVSLDHSMW FHAPFRADHW MLYECESPWA GGSRGLVHGR LWRQDGVLAV TCAQEGVIRV KPQVSESKL
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