About Protein arginine N-methyltransferase 5
Protein arginine N-methyltransferase 5 (PRMT5) is a protein
from Homo sapiens identified by UniProt accession
O14744, 637 residues long.
MolForge cross-references it against 0 known binders and
308 disease associations.
Target properties
| Protein name | Protein arginine N-methyltransferase 5 |
|---|
| UniProt accession | O14744 |
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| Gene | PRMT5 |
|---|
| Organism | Homo sapiens |
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| Length | 637 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (308)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.27
- low grade glioma · score 0.25
- ovarian cancer · score 0.23
- endometrial cancer · score 0.23
- gastric adenocarcinoma · score 0.21
- urinary bladder cancer · score 0.21
- neurodegenerative disease · score 0.21
- head and neck squamous cell carcinoma · score 0.21
- lung adenocarcinoma · score 0.21
- squamous cell lung carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14744-F1 | alphafold | PREDICTED | 93.31 | — |
Amino-acid sequence (637 residues)
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL
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