About Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) is a protein
from Homo sapiens identified by UniProt accession
O14745, 358 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
|---|
| UniProt accession | O14745 |
|---|
| Gene | NHERF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 358 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (208)
Diseases linked to this target (Open Targets).
- hypophosphatemic nephrolithiasis/osteoporosis 2 · score 0.67
- neutrophil count · score 0.37
- leukocyte count · score 0.33
- basophil count · score 0.32
- monocyte count · score 0.30
- nephrolithiasis · score 0.26
- Hypophosphatemia · score 0.26
- Red cell distribution width · score 0.26
- monocyte percentage of leukocytes · score 0.23
- lymphocyte percentage of leukocytes · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14745-F1 | alphafold | PREDICTED | 72.78 | — |
Amino-acid sequence (358 residues)
MSADAAAGAP LPRLCCLEKG PNGYGFHLHG EKGKLGQYIR LVEPGSPAEK AGLLAGDRLV EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDEQLQ KLGVQVREEL LRAQEAPGQA EPPAAAEVQG AGNENEPREA DKSHPEQREL RPRLCTMKKG PSGYGFNLHS DKSKPGQFIR SVDPDSPAEA SGLRAQDRIV EVNGVCMEGK QHGDVVSAIR AGGDETKLLV VDRETDEFFK KCRVIPSQEH LNGPLPVPFT NGEIQKENSR EALAEAALES PRPALVRSAS SDTSEELNSQ DSPPKQDSTA PSSTSSSDPI LDFNISLAMA KERAHQKRSS KRAPQMDWSK KNELFSNL
Explore Na(+)/H(+) exchange regulatory cofactor NHE-RF1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets