About 17-beta-hydroxysteroid dehydrogenase type 6
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) is a protein
from Homo sapiens identified by UniProt accession
O14756, 317 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | 17-beta-hydroxysteroid dehydrogenase type 6 |
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| UniProt accession | O14756 |
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| Gene | HSD17B6 |
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| Organism | Homo sapiens |
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| Length | 317 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (95)
Diseases linked to this target (Open Targets).
- microcephalic primordial dwarfism · score 0.33
- erythrocyte count · score 0.27
- lean body mass · score 0.23
- platelet count · score 0.22
- mean corpuscular volume · score 0.21
- monocyte count · score 0.20
- age at menopause · score 0.20
- BMI-adjusted waist-hip ratio · score 0.20
- neurodegenerative disease · score 0.19
- mean corpuscular hemoglobin · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14756-F1 | alphafold | PREDICTED | 95.89 | — |
Amino-acid sequence (317 residues)
MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD ARGLRVLAAC LTEKGAEQLR GQTSDRLETV TLDVTKMESI AAATQWVKEH VGDRGLWGLV NNAGILTPIT LCEWLNTEDS MNMLKVNLIG VIQVTLSMLP LVRRARGRIV NVSSILGRVA FFVGGYCVSK YGVEAFSDIL RREIQHFGVK ISIVEPGYFR TGMTNMTQSL ERMKQSWKEA PKHIKETYGQ QYFDALYNIM KEGLLNCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAKFF FIPLSYLPTS LADYILTRSW PKPAQAV
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