About Serine/threonine-protein kinase Chk1
Serine/threonine-protein kinase Chk1 (CHEK1) is a protein
from Homo sapiens identified by UniProt accession
O14757, 476 residues long.
MolForge cross-references it against 0 known binders and
380 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Chk1 |
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| UniProt accession | O14757 |
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| Gene | CHEK1 |
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| Organism | Homo sapiens |
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| Length | 476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (380)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- glioblastoma multiforme · score 0.30
- head and neck squamous cell carcinoma · score 0.29
- lung adenocarcinoma · score 0.29
- endometrial cancer · score 0.28
- Male infertility due to gonadal dysgenesis or sperm disorder · score 0.27
- squamous cell lung carcinoma · score 0.24
- gastric adenocarcinoma · score 0.23
- small cell lung carcinoma · score 0.22
- urinary bladder cancer · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14757-F1 | alphafold | PREDICTED | 76.14 | — |
Amino-acid sequence (476 residues)
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK IWLPAT
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