Gamma-aminobutyric acid receptor subunit delta (GABRD)

About Gamma-aminobutyric acid receptor subunit delta

Gamma-aminobutyric acid receptor subunit delta (GABRD) is a protein from Homo sapiens identified by UniProt accession O14764, 452 residues long. MolForge cross-references it against 0 known binders and 300 disease associations.

Target properties

Protein name	Gamma-aminobutyric acid receptor subunit delta
UniProt accession	O14764
Gene	GABRD
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (300)

Diseases linked to this target (Open Targets).

Generalized epilepsy with febrile seizures-plus · score 0.71
Seizure · score 0.61
epilepsy · score 0.61
pain · score 0.60
migraine disorder · score 0.60
alcohol dependence · score 0.59
delirium · score 0.59
obesity · score 0.58
coronary artery disease · score 0.58
Agitation · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14764-F1	alphafold	PREDICTED	79.16	—

Amino-acid sequence (452 residues)

MDAPARLLAP LLLLCAQQLR GTRAMNDIGD YVGSNLEISW LPNLDGLIAG YARNFRPGIG GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPMDEQECML DLESYGYSSE DIVYYWSESQ EHIHGLDKLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FHLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK QKAKVKVSRP RAEMDVRNAI VLFSLSAAGV TQELAISRRQ RRVPGNLMGS YRSVGVETGE TKKEGAARSG GQGGIRARLR PIDADTIDIY ARAVFPAAFA AVNVIYWAAY AM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards