Homeobox protein Meis2 (MEIS2)

About Homeobox protein Meis2

Homeobox protein Meis2 (MEIS2) is a protein from Homo sapiens identified by UniProt accession O14770, 477 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Homeobox protein Meis2
UniProt accession	O14770
Gene	MEIS2
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies · score 0.73
Cognitive impairment · score 0.53
genetic disorder · score 0.48
PHF-tau measurement · score 0.42
cortical surface area measurement · score 0.41
waist-hip ratio · score 0.41
BMI-adjusted waist-hip ratio · score 0.41
syndromic intellectual disability · score 0.37
response to risperidone · score 0.34
brain measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14770-F1	alphafold	PREDICTED	61.96	—

Amino-acid sequence (477 residues)

MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards