About Fucose-1-phosphate guanylyltransferase
Fucose-1-phosphate guanylyltransferase (FPGT) is a protein
from Homo sapiens identified by UniProt accession
O14772, 607 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Fucose-1-phosphate guanylyltransferase |
|---|
| UniProt accession | O14772 |
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| Gene | FPGT |
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| Organism | Homo sapiens |
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| Length | 607 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- health study participation · score 0.28
- self reported educational attainment · score 0.25
- mathematical ability · score 0.18
- cognitive function measurement · score 0.10
- lymphocyte count · score 0.08
- DNA methylation · score 0.07
- PHF-tau measurement · score 0.02
- cancer · score 0.01
- non-small cell lung carcinoma · score 0.01
- bacteriemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14772-F1 | alphafold | PREDICTED | 90.36 | — |
Amino-acid sequence (607 residues)
MRAVRRGLRE GGAMAAARDP PEVSLREATQ RKLRRFSELR GKLVARGEFW DIVAITAADE KQELAYNQQL SEKLKRKELP LGVQYHVFVD PAGAKIGNGG STLCALQCLE KLYGDKWNSF TILLIHSGGY SQRLPNASAL GKIFTALPLG NPIYQMLELK LAMYIDFPLN MNPGILVTCA DDIELYSIGE FEFIRFDKPG FTALAHPSSL TIGTTHGVFV LDPFDDLKHR DLEYRSCHRF LHKPSIEKMY QFNAVCRPGN FCQQDFAGGD IADLKLDSDY VYTDSLFYMD HKSAKMLLAF YEKIGTLSCE IDAYGDFLQA LGPGATVEYT RNTSNVIKEE SELVEMRQRI FHLLKGTSLN VVVLNNSKFY HIGTTEEYLF YFTSDNSLKS ELGLQSITFS IFPDIPECSG KTSCIIQSIL DSRCSVAPGS VVEYSRLGPD VSVGENCIIS GSYILTKAAL PAHSFVCSLS LKMNRCLKYA TMAFGVQDNL KKSVKTLSDI KLLQFFGVCF LSCLDVWNLK VTEELFSGNK TCLSLWTARI FPVCSSLSDS VITSLKMLNA VKNKSAFSLN SYKLLSIEEM LIYKDVEDMI TYREQIFLEI SLKSSLM
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