About Tripeptidyl-peptidase 1
Tripeptidyl-peptidase 1 (TPP1) is a protein
from Homo sapiens identified by UniProt accession
O14773, 563 residues long.
MolForge cross-references it against 0 known binders and
487 disease associations.
Target properties
| Protein name | Tripeptidyl-peptidase 1 |
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| UniProt accession | O14773 |
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| Gene | TPP1 |
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| Organism | Homo sapiens |
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| Length | 563 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (487)
Diseases linked to this target (Open Targets).
- neuronal ceroid lipofuscinosis 2 · score 0.85
- CLN2 disease · score 0.82
- Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia · score 0.74
- autosomal recessive spinocerebellar ataxia 7 · score 0.73
- neuronal ceroid lipofuscinosis · score 0.69
- genetic disorder · score 0.53
- Intellectual disability · score 0.50
- Abnormality of the nervous system · score 0.46
- hereditary ataxia · score 0.46
- hereditary nonpolyposis colon cancer · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14773-F1 | alphafold | PREDICTED | 90.48 | — |
Amino-acid sequence (563 residues)
MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLHTVQ KWLLAAGAQK CHSVITQDFL TCWLSIRQAE LLLPGAEFHH YVGGPTETHV VRSPHPYQLP QALAPHVDFV GGLHRFPPTS SLRQRPEPQV TGTVGLHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP GWDPVTGWGT PNFPALLKTL LNP
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