About Guanine nucleotide-binding protein subunit beta-5
Guanine nucleotide-binding protein subunit beta-5 (GNB5) is a protein
from Homo sapiens identified by UniProt accession
O14775, 395 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein subunit beta-5 |
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| UniProt accession | O14775 |
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| Gene | GNB5 |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- gnb5-related intellectual disability-cardiac arrhythmia syndrome · score 0.74
- language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia · score 0.65
- genetic disorder · score 0.49
- Global developmental delay · score 0.33
- anxiety · score 0.32
- vitamin D measurement · score 0.32
- endometrial cancer · score 0.28
- Abnormality of the nervous system · score 0.27
- attention deficit hyperactivity disorder · score 0.26
- head and neck squamous cell carcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14775-F1 | alphafold | PREDICTED | 93.98 | — |
Amino-acid sequence (395 residues)
MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE NETLASLKSE AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV MACAYAPSGC AIACGGLDNK CSVYPLTFDK NENMAAKKKS VAMHTNYLSA CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV LCLDLAPSET GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDINSVRYY PSGDAFASGS DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN VWDVLKGSRV SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA
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