Apolipoprotein L1 (APOL1)

About Apolipoprotein L1

Apolipoprotein L1 (APOL1) is a protein from Homo sapiens identified by UniProt accession O14791, 398 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.

Target properties

Protein name	Apolipoprotein L1
UniProt accession	O14791
Gene	APOL1
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (279)

Diseases linked to this target (Open Targets).

focal segmental glomerulosclerosis · score 0.68
sporadic idiopathic steroid-resistant nephrotic syndrome · score 0.46
steroid-resistant nephrotic syndrome · score 0.42
Proteinuria · score 0.42
glomerulonephritis · score 0.42
trypanosomiasis · score 0.37
blood protein measurement · score 0.35
chronic kidney disease · score 0.32
type 2 diabetes mellitus · score 0.28
diabetic nephropathy · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14791-F1	alphafold	PREDICTED	51.91	—

Amino-acid sequence (398 residues)

MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards