Growth/differentiation factor 8 (MSTN)

About Growth/differentiation factor 8

Growth/differentiation factor 8 (MSTN) is a protein from Homo sapiens identified by UniProt accession O14793, 375 residues long. MolForge cross-references it against 0 known binders and 615 disease associations.

Target properties

Protein name	Growth/differentiation factor 8
UniProt accession	O14793
Gene	MSTN
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (615)

Diseases linked to this target (Open Targets).

myostatin-related muscle hypertrophy · score 0.51
spinal muscular atrophy, type III · score 0.32
creatinine measurement · score 0.29
Atrophy · score 0.26
proximal spinal muscular atrophy · score 0.26
lean body mass · score 0.16
Duchenne muscular dystrophy · score 0.12
cancer · score 0.11
sarcopenia · score 0.11
Rheumatoid arthritis · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14793-F1	alphafold	PREDICTED	78.78	—

Amino-acid sequence (375 residues)

MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEAIKIQI LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII YGKIPAMVVD RCGCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards