About SH2 domain-containing protein 1B
SH2 domain-containing protein 1B (SH2D1B) is a protein
from Homo sapiens identified by UniProt accession
O14796, 132 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | SH2 domain-containing protein 1B |
|---|
| UniProt accession | O14796 |
|---|
| Gene | SH2D1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 132 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (57)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.25
- lymphocyte percentage of leukocytes · score 0.18
- monocyte percentage of leukocytes · score 0.06
- monocyte count · score 0.06
- Chronic mucocutaneous candidosis · score 0.06
- QT interval · score 0.05
- Wiskott-Aldrich syndrome · score 0.05
- granulocyte percentage of myeloid white cells · score 0.05
- mean reticulocyte volume · score 0.05
- hyper-IgM syndrome type 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14796-F1 | alphafold | PREDICTED | 80.25 | — |
Amino-acid sequence (132 residues)
MDLPYYHGRL TKQDCETLLL KEGVDGNFLL RDSESIPGVL CLCVSFKNIV YTYRIFREKH GYYRIQTAEG SPKQVFPSLK ELISKFEKPN QGMVVHLLKP IKRTSPSLRW RGLKLELETF VNSNSDYVDV LP
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