About Ras-related protein M-Ras
Ras-related protein M-Ras (MRAS) is a protein
from Homo sapiens identified by UniProt accession
O14807, 208 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Ras-related protein M-Ras |
|---|
| UniProt accession | O14807 |
|---|
| Gene | MRAS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 208 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- Noonan syndrome · score 0.75
- coronary artery disease · score 0.46
- body mass index · score 0.42
- BMI-adjusted waist-hip ratio · score 0.41
- rasopathy · score 0.41
- physical activity measurement · score 0.40
- body fat percentage · score 0.40
- diastolic blood pressure · score 0.38
- cardiovascular disease · score 0.37
- systolic blood pressure · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14807-F1 | alphafold | PREDICTED | 86.40 | — |
Amino-acid sequence (208 residues)
MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT HKLQCVIL
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