Complexin-1 (CPLX1)

About Complexin-1

Complexin-1 (CPLX1) is a protein from Homo sapiens identified by UniProt accession O14810, 134 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Complexin-1
UniProt accession	O14810
Gene	CPLX1
Organism	Homo sapiens
Length	134 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy · score 0.58
familial infantile myoclonic epilepsy · score 0.37
Abnormal brain morphology · score 0.27
genetic disorder · score 0.18
head and neck squamous cell carcinoma · score 0.11
appendicular lean mass · score 0.09
fat body mass · score 0.08
schizophrenia · score 0.08
lean body mass · score 0.06
hip circumference · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14810-F1	alphafold	PREDICTED	71.45	—

Amino-acid sequence (134 residues)

MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards