Paired mesoderm homeobox protein 2A (PHOX2A)

About Paired mesoderm homeobox protein 2A

Paired mesoderm homeobox protein 2A (PHOX2A) is a protein from Homo sapiens identified by UniProt accession O14813, 284 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Paired mesoderm homeobox protein 2A
UniProt accession	O14813
Gene	PHOX2A
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

congenital fibrosis of the extraocular muscles · score 0.59
neurodegenerative disease · score 0.42
congenital fibrosis of extraocular muscles · score 0.37
Parkinson disease · score 0.25
lysosomal storage disease · score 0.25
Alzheimer disease · score 0.25
multiple sclerosis · score 0.25
genetic disorder · score 0.18
MODY · score 0.08
type 2 diabetes mellitus · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14813-F1	alphafold	PREDICTED	62.67	—

Amino-acid sequence (284 residues)

MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA AGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPGL ASPRLSPSPL PVALGSGPGP GPGPQPLKGA LWAGVAGGGG GGPGAGAAEL LKAWQPAESG PGPFSGVLSS FHRKPGPALK TNLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards