About Tetraspanin-4
Tetraspanin-4 (TSPAN4) is a protein
from Homo sapiens identified by UniProt accession
O14817, 238 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Tetraspanin-4 |
|---|
| UniProt accession | O14817 |
|---|
| Gene | TSPAN4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- body mass index · score 0.22
- lean body mass · score 0.21
- body weight · score 0.21
- body fat percentage · score 0.13
- hip circumference · score 0.11
- base metabolic rate measurement · score 0.09
- glioblastoma multiforme · score 0.09
- whole body water mass · score 0.08
- lung adenocarcinoma · score 0.08
- systolic blood pressure · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14817-F1 | alphafold | PREDICTED | 89.70 | — |
Amino-acid sequence (238 residues)
MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS LSAANLLIIT GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI AILFFAYTDK IDRYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC YETVKVWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA
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