About Proteasome subunit alpha type-7
Proteasome subunit alpha type-7 (PSMA7) is a protein
from Homo sapiens identified by UniProt accession
O14818, 248 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-7 |
|---|
| UniProt accession | O14818 |
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| Gene | PSMA7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.29
- glioblastoma multiforme · score 0.28
- gastric adenocarcinoma · score 0.27
- multiple myeloma · score 0.25
- mean reticulocyte volume · score 0.21
- alkaline phosphatase measurement · score 0.18
- blood phosphate measurement · score 0.17
- mean corpuscular volume · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14818-F1 | alphafold | PREDICTED | 94.37 | — |
Amino-acid sequence (248 residues)
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE KKKQKKAS
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