About Serine/threonine-protein phosphatase with EF-hands 1
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF1) is a protein
from Homo sapiens identified by UniProt accession
O14829, 653 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase with EF-hands 1 |
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| UniProt accession | O14829 |
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| Gene | PPEF1 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.11
- breast cancer · score 0.07
- gastric adenocarcinoma · score 0.02
- cancer · score 0.02
- Abnormal sperm morphology · score 0.02
- central nervous system cancer · score 0.01
- X-linked retinoschisis · score 0.01
- Methicillin-Resistant Staphylococcus Aureus Infection · score 0.01
- astrocytoma · score 0.01
- glioblastoma multiforme · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14829-F1 | alphafold | PREDICTED | 80.57 | — |
Amino-acid sequence (653 residues)
MGCSSSSTKT RRSDTSLRAA LIIQNWYRGY KARLKARQHY ALTIFQSIEY ADEQGQMQLS TFFSFMLENY THIHKEELEL RNQSLESEQD MRDRWDYVDS IDVPDSYNGP RLQFPLTCTD IDLLLEAFKE QQILHAHYVL EVLFETKKVL KQMPNFTHIQ TSPSKEVTIC GDLHGKLDDL FLIFYKNGLP SERNPYVFNG DFVDRGKNSI EILMILCVSF LVYPNDLHLN RGNHEDFMMN LRYGFTKEIL HKYKLHGKRI LQILEEFYAW LPIGTIVDNE ILVIHGGISE TTDLNLLHRV ERNKMKSVLI PPTETNRDHD TDSKHNKVGV TFNAHGRIKT NGSPTEHLTE HEWEQIIDIL WSDPRGKNGC FPNTCRGGGC YFGPDVTSKI LNKYQLKMLI RSHECKPEGY EICHDGKVVT IFSASNYYEE GSNRGAYIKL CSGTTPRFFQ YQVTKATCFQ PLRQRVDTME NSAIKILRER VISRKSDLTR AFQLQDHRKS GKLSVSQWAF CMENILGLNL PWRSLSSNLV NIDQNGNVEY MSSFQNIRIE KPVQEAHSTL VETLYRYRSD LEIIFNAIDT DHSGLISVEE FRAMWKLFSS HYNVHIDDSQ VNKLANIMDL NKDGSIDFNE FLKAFYVVHR YEDLMKPDVT NLG
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