About Serine/threonine-protein phosphatase with EF-hands 2
Serine/threonine-protein phosphatase with EF-hands 2 (PPEF2) is a protein
from Homo sapiens identified by UniProt accession
O14830, 753 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase with EF-hands 2 |
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| UniProt accession | O14830 |
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| Gene | PPEF2 |
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| Organism | Homo sapiens |
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| Length | 753 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.11
- cerebrospinal fluid biomarker measurement · score 0.09
- N-acylethanolamine-hydrolyzing acid amidase measurement · score 0.08
- protein measurement · score 0.02
- myopia · score 0.01
- Myopia · score 0.01
- Haim-Munk syndrome · score 0.01
- pancreatic adenocarcinoma · score 0.01
- hepatocellular carcinoma · score 0.01
- retinal degeneration · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14830-F1 | alphafold | PREDICTED | 75.19 | — |
Amino-acid sequence (753 residues)
MGSGTSTQHH FAFQNAERAF KAAALIQRWY RRYVARLEMR RRCTWSIFQS IEYAGQQDQV KLHDFFSYLM DHFIPSSHND RDFLTRIFTE DRFAQDSEMK KCSDYESIEV PDSYTGPRLS FPLLPDHATA LVEAFRLKQQ LHARYVLNLL YETKKHLVQL PNINRVSTCY SEEITVCGDL HGQLDDLIFI FYKNGLPSPE RSYVFNGDFV DRGKDSVEIL MILFAFMLVY PKEFHLNRGN HEDHMVNLRY GFTKEVMNKY KVHGKEILRT LQDVFCWLPL ATLIDEKVLI LHGGVSDITD LELLDKIERS KIVSTMRCKT RQKSEKQMEE KRRANQKSSA QGPIPWFLPE SRSLPSSPLR LGSYKAQKTS RSSSIPCSGS LDGRELSRQV RSSVELELER CRQQAGLLVT GEKEEPSRSA SEADSEAGEL RKPTQEEWRQ VVDILWSDPM AQEGCKANTI RGGGCYFGPD VTQQLLQKYN MQFLIRSHEC KPEGYEFCHN RKVLTIFSAS NYYEVGSNRG AYVKLGPALT PHIVQYQANK VTHTLTMRQR ISRVEESALR ALREKLFAHS SDLLSEFKKH DADKVGLITL SDWAAAVESV LHLGLPWRML RPQLVNSSAD NMLEYKSWLK NLAKEQLSRE NIQSSLLETL YRNRSNLETI FRIIDSDHSG FISLDEFRQT WKLFSSHMNI DITDDCICDL ARSIDFNKDG HIDINEFLEA FRLVEKSCPE GDASECPQAT NAKDSGCSSP GAH
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