Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

About Phytanoyl-CoA dioxygenase, peroxisomal

Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) is a protein from Homo sapiens identified by UniProt accession O14832, 338 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Phytanoyl-CoA dioxygenase, peroxisomal
UniProt accession	O14832
Gene	PHYH
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

Refsum disease · score 0.83
adult Refsum disease · score 0.66
retinitis pigmentosa · score 0.46
Retinal dystrophy · score 0.44
genetic disorder · score 0.41
phytanoyl-CoA hydroxylase deficiency · score 0.37
Orofacial cleft · score 0.35
sex hormone-binding globulin measurement · score 0.25
neurodegenerative disease · score 0.16
nonpapillary renal cell carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14832-F1	alphafold	PREDICTED	85.45	—

Amino-acid sequence (338 residues)

MEQLRAAARL QIVLGHLGRP SAGAVVAHPT SGTISSASFH PQQFQYTLDN NVLTLEQRKF YEENGFLVIK NLVPDADIQR FRNEFEKICR KEVKPLGLTV MRDVTISKSE YAPSEKMITK VQDFQEDKEL FRYCTLPEIL KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHY FPFRPSDLIV CAWTAMEHIS RNNGCLVVLP GTHKGSLKPH DYPKWEGGVN KMFHGIQDYE ENKARVHLVM EKGDTVFFHP LLIHGSGQNK TQGFRKAISC HFASADCHYI DVKGTSQENI EKEVVGIAHK FFGAENSVNL KDIWMFRARL VKGERTNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards