Interferon-inducible protein AIM2 (AIM2)

About Interferon-inducible protein AIM2

Interferon-inducible protein AIM2 (AIM2) is a protein from Homo sapiens identified by UniProt accession O14862, 343 residues long. MolForge cross-references it against 0 known binders and 576 disease associations.

Target properties

Protein name	Interferon-inducible protein AIM2
UniProt accession	O14862
Gene	AIM2
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (576)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.34
psoriasis · score 0.23
protein measurement · score 0.19
ovarian cancer · score 0.18
self reported educational attainment · score 0.17
mathematical ability · score 0.17
asthma · score 0.16
CCL2 measurement · score 0.15
lung adenocarcinoma · score 0.13
hereditary breast ovarian cancer syndrome · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14862-F1	alphafold	PREDICTED	83.77	—

Amino-acid sequence (343 residues)

MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards