About Probable proton-coupled zinc antiporter SLC30A4
Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4) is a protein
from Homo sapiens identified by UniProt accession
O14863, 429 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Probable proton-coupled zinc antiporter SLC30A4 |
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| UniProt accession | O14863 |
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| Gene | SLC30A4 |
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| Organism | Homo sapiens |
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| Length | 429 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.06
- acheiropody · score 0.05
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.05
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.05
- Acromesomelic dysplasia, Hunter-Thomson type · score 0.05
- Blount disease · score 0.04
- acromesomelic dysplasia 2A · score 0.04
- tibial hemimelia · score 0.04
- syndactyly type 4 · score 0.04
- Gollop-Wolfgang complex · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14863-F1 | alphafold | PREDICTED | 72.66 | — |
Amino-acid sequence (429 residues)
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT CANCQSSSP
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