About Branched-chain alpha-ketoacid dehydrogenase kinase
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) is a protein
from Homo sapiens identified by UniProt accession
O14874, 412 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Branched-chain alpha-ketoacid dehydrogenase kinase |
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| UniProt accession | O14874 |
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| Gene | BCKDK |
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| Organism | Homo sapiens |
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| Length | 412 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- branched-chain keto acid dehydrogenase kinase deficiency · score 0.75
- Intellectual disability · score 0.44
- protein measurement · score 0.42
- branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid measurement · score 0.32
- valine measurement · score 0.24
- neuroinflammatory disorder · score 0.22
- genetic disorder · score 0.19
- body mass index · score 0.17
- isoleucine measurement · score 0.16
- maple syrup urine disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14874-F1 | alphafold | PREDICTED | 83.21 | — |
Amino-acid sequence (412 residues)
MILASVLRSG PGGGLPLRPL LGPALALRAR STSATDTHHV EMARERSKTV TSFYNQSAID AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV RIAHRIKGFR CLPFIIGCNP TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGAQS GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI
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