About Interferon-induced protein with tetratricopeptide repeats 3
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a protein
from Homo sapiens identified by UniProt accession
O14879, 490 residues long.
MolForge cross-references it against 0 known binders and
191 disease associations.
Target properties
| Protein name | Interferon-induced protein with tetratricopeptide repeats 3 |
|---|
| UniProt accession | O14879 |
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| Gene | IFIT3 |
|---|
| Organism | Homo sapiens |
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| Length | 490 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (191)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.19
- Systemic lupus erythematosus · score 0.10
- myocardial infarction · score 0.09
- systemic lupus erythematosus · score 0.08
- alkaline phosphatase measurement · score 0.08
- acute promyelocytic leukemia · score 0.08
- blood protein measurement · score 0.08
- neoplasm · score 0.07
- primary biliary cirrhosis · score 0.07
- Red cell distribution width · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14879-F1 | alphafold | PREDICTED | 74.59 | — |
Amino-acid sequence (490 residues)
MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR ELLSNSEQLN
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